Protein interaction networks in innate immunity.

Details

Serval ID
serval:BIB_2775A69447A8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Protein interaction networks in innate immunity.
Journal
Trends in immunology
Author(s)
Rebsamen M., Kandasamy R.K., Superti-Furga G.
ISSN
1471-4981 (Electronic)
ISSN-L
1471-4906
Publication state
Published
Issued date
12/2013
Peer-reviewed
Oui
Volume
34
Number
12
Pages
610-619
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host-pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.
Keywords
Humans, Immunity, Innate/genetics, Immunity, Innate/immunology, Protein Interaction Maps/genetics, Protein Interaction Maps/immunology, Proteome/genetics, Proteome/immunology, Proteomics/methods, Signal Transduction/genetics, Signal Transduction/immunology, innate immunity, mass spectrometry, protein complex, proteomics, systems biology
Pubmed
Web of science
Create date
11/08/2020 17:06
Last modification date
13/08/2020 6:26
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