Structure and Plasticity of Indoleamine 2,3-Dioxygenase 1 (IDO1).

Details

Serval ID
serval:BIB_27218E957A69
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Structure and Plasticity of Indoleamine 2,3-Dioxygenase 1 (IDO1).
Journal
Journal of medicinal chemistry
Author(s)
Röhrig U.F., Michielin O., Zoete V.
ISSN
1520-4804 (Electronic)
ISSN-L
0022-2623
Publication state
Published
Issued date
23/12/2021
Peer-reviewed
Oui
Volume
64
Number
24
Pages
17690-17705
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Since the discovery of the implication of indoleamine 2,3-dioxygenase 1 (IDO1) in tumoral immune resistance in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies, supported by the publication of the first crystal structure of IDO1 in 2006. More recently, it has become clear that IDO1 is an important player in various biological pathways and diseases ranging from neurodegenerative diseases to infection and autoimmunity. Its inhibition may lead to clinical benefit in different therapeutic settings. At present, over 50 experimental structures of IDO1 in complex with different ligands are available in the Protein Data Bank. Our analysis of this wealth of structural data sheds new light on several open issues regarding IDO1's structure and function.
Pubmed
Web of science
Create date
20/12/2021 13:41
Last modification date
08/01/2022 7:33
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