Unravelling HIV-1 Latency, One Cell at a Time.

Details

Serval ID
serval:BIB_26F267BF53BE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Unravelling HIV-1 Latency, One Cell at a Time.
Journal
Trends in microbiology
Author(s)
Kok Y.L., Ciuffi A., Metzner K.J.
ISSN
1878-4380 (Electronic)
ISSN-L
0966-842X
Publication state
Published
Issued date
11/2017
Peer-reviewed
Oui
Volume
25
Number
11
Pages
932-941
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on the host cell. Here, using the human immunodeficiency virus type 1 (HIV-1) as an example, we summarize the current knowledge and the future potential of single-cell omics in the investigation of an important aspect of the life cycle of HIV-1 that represents a major hurdle in achieving viral eradication, HIV-1 latency.

Keywords
Genomics, HIV Infections/virology, HIV-1/growth & development, Host-Pathogen Interactions, Humans, Metabolomics, Single-Cell Analysis/methods, Virus Latency/physiology, HIV-1 integration sites, human immunodeficiency virus type 1, single-cell omics, viral latency
Pubmed
Web of science
Create date
27/07/2017 15:35
Last modification date
20/08/2019 13:05
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