Application de la modélisation moléculaire à de nouvelles approches thérapeutiques du cancer [Application of molecular modeling to new therapeutic cancer approaches].

Details

Serval ID
serval:BIB_26EE513BE64A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Application de la modélisation moléculaire à de nouvelles approches thérapeutiques du cancer [Application of molecular modeling to new therapeutic cancer approaches].
Journal
Bulletin du Cancer
Author(s)
Michielin O.
ISSN
1769-6917 (Electronic)
ISSN-L
0007-4551
Publication state
Published
Issued date
2007
Volume
94
Number
9
Pages
763-768
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Recent progress in the experimental determination of protein structures allow to understand, at a very detailed level, the molecular recognition mechanisms that are at the basis of the living matter. This level of understanding makes it possible to design rational therapeutic approaches, in which effectors molecules are adapted or created de novo to perform a given function. An example of such an approach is drug design, were small inhibitory molecules are designed using in silico simulations and tested in vitro. In this article, we present a similar approach to rationally optimize the sequence of killer T lymphocytes receptors to make them more efficient against melanoma cells. The architecture of this translational research project is presented together with its implications both at the level of basic research as well as in the clinics.
Keywords
Amino Acid Sequence, Amino Acid Substitution, Antigens, Neoplasm/immunology, Computer Simulation, Conserved Sequence, Humans, Immunotherapy, Adoptive, Melanoma/immunology, Melanoma/therapy, Membrane Proteins/immunology, Models, Molecular, Molecular Sequence Data, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/chemistry, Protein Conformation, Protein Engineering/methods, Protein Interaction Mapping, Receptors, Antigen, T-Cell/chemistry, Receptors, Antigen, T-Cell/immunology, Sequence Alignment, Structure-Activity Relationship, T-Cell Antigen Receptor Specificity, T-Lymphocytes, Cytotoxic/chemistry, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Create date
28/01/2008 11:22
Last modification date
20/08/2019 13:05
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