Judgments of trained observers on adverse drug reactions

Details

Serval ID
serval:BIB_26EA066F8D16
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Judgments of trained observers on adverse drug reactions
Journal
Clinical Pharmacology and Therapeutics
Author(s)
Blanc  S., Leuenberger  P., Berger  J. P., Brooke  E. M., Schelling  J. L.
ISSN
0009-9236 (Print)
Publication state
Published
Issued date
05/1979
Volume
25
Number
5 Pt 1
Pages
493-8
Notes
Journal Article --- Old month value: May
Abstract
Patients (672) admitted to a department of medicine during five consecutive months were followed by an investigator who identified 110 clinical manifestations which could have been considered adverse drug reactions. From these, 42 were excluded because they did not correspond to the definition of adverse reaction or they were inadequately documented. The remaining 68 cases were submitted to three independent observers who had to reply to a series of questions; from these replies five degrees of probability for the reaction itself were deduced. Reactions (54; 49% of the manifestations reported) were considered as certain or probable by at least two observers, but only 27 rections of these (25%) were attributed to the same drug by all three observers. There was a low level of agreement between any two observers (paired agreement ratio: 0.6 to 0.7) and little difference of agreement between any one observer and each of the others (personal agreement ratio: 0.6 to 0.7).
Keywords
Drug Therapy/*adverse effects Humans Nurses Physicians Research Design *Research Personnel Time Factors
Pubmed
Web of science
Create date
25/01/2008 9:50
Last modification date
20/08/2019 13:05
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