T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

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Ressource 1Download: Utzschneider at al 2016 author copy.pdf (3211.14 [Ko])
State: Public
Version: Author's accepted manuscript
License: CC BY 4.0
Serval ID
serval:BIB_26E58D22D474
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.
Journal
Immunity
Author(s)
Utzschneider D.T., Charmoy M., Chennupati V., Pousse L., Ferreira D.P., Calderon-Copete S., Danilo M., Alfei F., Hofmann M., Wieland D., Pradervand S., Thimme R., Zehn D., Held W.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
16/08/2016
Peer-reviewed
Oui
Volume
45
Number
2
Pages
415-427
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Chronic infections promote the terminal differentiation (or "exhaustion") of T cells and are thought to preclude the formation of memory T cells. In contrast, we discovered a small subpopulation of virus-specific CD8(+) T cells that sustained the T cell response during chronic infections. These cells were defined by, and depended on, the expression of the transcription factor Tcf1. Transcriptome analysis revealed that this population shared key characteristics of central memory cells but lacked an effector signature. Unlike conventional memory cells, Tcf1-expressing T cells displayed hallmarks of an "exhausted" phenotype, including the expression of inhibitory receptors such as PD-1 and Lag-3. This population was crucial for the T cell expansion that occurred in response to inhibitory receptor blockade during chronic infection. These findings identify a memory-like T cell population that sustains T cell responses and is a prime target for therapeutic interventions to improve the immune response in chronic infections.
Pubmed
Open Access
Yes
Create date
24/01/2017 10:42
Last modification date
16/07/2020 8:43
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