Physiopathologie cardio-vasculaire des hormones ovariennes. [Cardiovascular physiopathology of ovarian hormones]

Details

Serval ID
serval:BIB_26DAB2662F1E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Physiopathologie cardio-vasculaire des hormones ovariennes. [Cardiovascular physiopathology of ovarian hormones]
Journal
Schweizerische Rundschau fur Medizin Praxis
Author(s)
de Ziegler  D.
ISSN
1013-2058
Publication state
Published
Issued date
01/1997
Volume
86
Number
5
Pages
138-44
Notes
English Abstract
Journal Article
Review --- Old month value: Jan 28
Abstract
Epidemiological data indicate that women are less likely to suffer from coronary heart disease (CHD) than men of the same age. This difference vanishes however after menopause suggesting that it is the hormones produced by the ovaries that are responsible for the relative cardioprotection that women enjoy before menopause. In spite of the favorable impact of oral estrogen treatments on the lipid profile it is believed today that estrogens act mainly through direct effects on vessels. Estrogens have vasodilative properties, exert anti proliferative effects on the endothelium and alter the response of vessels to various stimuli (vaso-reactivity) such as Acetylcholine (Ach). Direct assessment of large vessel wall thickness or Intima Media Thickness (IMT) is considered as the most predictive parameter of cardiovascular risk today and may serve to single out women who must receive HRT for cardiovascular reasons.
Keywords
Adolescent Adult Aged Aged, 80 and over Animals Cardiovascular Diseases/*prevention & control Cardiovascular System/*drug effects Child *Estrogen Replacement Therapy Estrogens/pharmacology Female Humans Lipids/blood Macaca fascicularis Male Middle Aged Muscle, Smooth, Vascular/drug effects Risk Factors Vascular Resistance/drug effects Vasodilation/drug effects
Pubmed
Create date
28/02/2008 11:36
Last modification date
20/08/2019 13:05
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