New emerging tasks for microRNAs in the control of β-cell activities

Details

Ressource 1Download: BIB_26D955FDA835.P001.pdf (1092.95 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_26D955FDA835
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New emerging tasks for microRNAs in the control of β-cell activities
Journal
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Author(s)
Guay Claudiane, Regazzi Romano
ISSN
1388-1981
ISSN-L
1879-2618
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
1861
Number
12
Pages
2121-2129
Language
english
Abstract
MicroRNAs are key regulators of β-cell physiology. They participate to the differentiation of insulin-producing cells and are instrumental for the acquisition of their unique secretory properties. Moreover, they contribute to the adaptation of β-cells to conditions of increased insulin demand and, if expressed at inappropriate levels, certain microRNAs cause β-cell dysfunction and promote the development of different forms of diabetes mellitus. While these functions are increasingly better understood, additional tasks for these small non-coding RNAs have been recently unveiled. Thus, microRNAs are emerging as signaling molecules of a novel exosome-mediated cell-to-cell communication mode permitting a coordinated response of the β-cells to inflammatory conditions and to modifications in the insulin demand. These discoveries raise a number of important issues that once addressed promise to shed new light on the molecular mechanism governing the functions of the β-cells under normal and disease states. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.

Keywords
Cell Biology, Molecular Biology
Pubmed
Create date
31/05/2016 16:47
Last modification date
20/08/2019 13:05
Usage data