Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.

Details

Serval ID
serval:BIB_26B277C44B60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
Journal
JAMA surgery
Author(s)
Zaborowski A.M., Abdile A., Adamina M., Aigner F., d'Allens L., Allmer C., Álvarez A., Anula R., Andric M., Atallah S., Bach S., Bala M., Barussaud M., Bausys A., Bebington B., Beggs A., Bellolio F., Bennett M.R., Berdinskikh A., Bevan V., Biondo S., Bislenghi G., Bludau M., Boutall A., Brouwer N., Brown C., Bruns C., Buchanan D.D., Buchwald P., Burger JWA, Burlov N., Campanelli M., Capdepont M., Carvello M., Chew H.H., Christoforidis D., Clark D., Climent M., Cologne K.G., Contreras T., Croner R., Daniels I.R., Dapri G., Davies J., Delrio P., Denost Q., Deutsch M., Dias A., D'Hoore A., Drozdov E., Duek D., Dunlop M., Dziki A., Edmundson A., Efetov S., El-Hussuna A., Elliot B., Emile S., Espin E., Evans M., Faes S., Faiz O., Fleming F., Foppa C., Fowler G., Frasson M., Figueiredo N., Forgan T., Frizelle F., Gadaev S., Gellona J., Glyn T., Gong J., Goran B., Greenwood E., Guren M.G., Guillon S., Gutlic I., Hahnloser D., Hampel H., Hanly A., Hasegawa H., Iversen L.H., Hill A., Hill J., Hoch J., Hoffmeister M., Hompes R., Hurtado L., Iaquinandi F., Imbrasaite U., Islam R., Jafari M.D., Kanemitsu Y., Karachun A., Karimuddin A.A., Keller D.S., Kelly J., Kennelly R., Khrykov G., Kocian P., Koh C., Kok N., Knight K.A., Knol J., Kontovounisios C., Korner H., Krivokapic Z., Kronberger I., Kroon H.M., Kryzauskas M., Kural S., Kusters M., Lakkis Z., Lankov T., Larson D., Lázár G., Lee K.Y., Lee S.H., Lefèvre J.H., Lepisto A., Lieu C., Loi L., Lynch C., Maillou-Martinaud H., Maroli A., Martin S., Martling A., Matzel K.E., Mayol J., McDermott F., Meurette G., Millan M., Mitteregger M., Moiseenko A., Monson JRT, Morarasu S., Moritani K., Möslein G., Munini M., Nahas C., Nahas S., Negoi I., Novikova A., Ocares M., Okabayashi K., Olkina A., Oñate-Ocaña L., Otero J., Ozen C., Pace U., São Julião G.P., Panaiotti L., Panis Y., Papamichael D., Park J., Patel S., Patrón Uriburu J.C., Pera M., Perez R.O., Petrov A., Pfeffer F., Phang P.T., Poskus T., Pringle H., Proud D., Raguz I., Rama N., Rasheed S., Raval M.J., Rega D., Reissfelder C., Reyes Meneses J.C., Ris F., Riss S., Rodriguez-Zentner H., Roxburgh C.S., Saklani A., Salido A.J., Sammour T., Saraste D., Schneider M., Seishima R., Sekulic A., Seppala T., Sheahan K., Shine R., Shlomina A., Sica G.S., Singnomklao T., Siragusa L., Smart N., Solis A., Spinelli A., Staiger R.D., Stamos M.J., Steele S., Sunderland M., Tan K.K., Tanis P.J., Tekkis P., Teklay B., Tengku S., Jiménez-Toscano M., Tsarkov P., Turina M., Ulrich A., Vailati B.B., van Harten M., Verhoef K., Warrier S., Wexner S., de Wilt H., Weinberg B.A., Wells C., Wolthuis A., Xynos E., You N., Zakharenko A., Zeballos J., Winter D.C.
Working group(s)
REACCT Collaborative
ISSN
2168-6262 (Electronic)
ISSN-L
2168-6254
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.
Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.
The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
Pubmed
Web of science
Create date
06/07/2021 11:11
Last modification date
13/08/2021 6:38
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