Human genomics of the humoral immune response against polyomaviruses.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_26ADA2C3DBC1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human genomics of the humoral immune response against polyomaviruses.
Journal
Virus evolution
Author(s)
Hodel F., Chong A.Y., Scepanovic P., Xu Z.M., Naret O., Thorball C.W., Rüeger S., Marques-Vidal P., Vollenweider P., Begemann M., Ehrenreich H., Brenner N., Bender N., Waterboer T., Mentzer A.J., Hill AVS, Hammer C., Fellay J.
ISSN
2057-1577 (Print)
ISSN-L
2057-1577
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
7
Number
2
Pages
veab058
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta-analyses of qualitative and quantitative immunoglobulin G responses against BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), Merkel cellpolyomavirus (MCPyV), WU polyomavirus (WUPyV), and human polyomavirus 6 (HPyV6) in 15,660 individuals of European ancestry from three independent studies. We observed significant associations for all tested viruses: JCPyV, HPyV6, and MCPyV associated with human leukocyte antigen class II variation, BKPyV and JCPyV with variants in FUT2, responsible for secretor status, MCPyV with variants in STING1, involved in interferon induction, and WUPyV with a functional variant in MUC1, previously associated with risk for gastric cancer. These results provide insights into the genetic control of a family of very prevalent human viruses, highlighting genes and pathways that play a modulating role in human humoral immunity.
Keywords
GWAS, genomics, human, infection, meta-analysis, polyomavirus
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2021 11:52
Last modification date
01/04/2022 6:34
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