Ca(2+) signaling by T-type Ca(2+) channels in neurons.

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Serval ID
serval:BIB_26A013793E82
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ca(2+) signaling by T-type Ca(2+) channels in neurons.
Journal
Pflügers Archiv
Author(s)
Cueni L., Canepari M., Adelman J.P., Lüthi A.
ISSN
0031-6768
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
457
Number
5
Pages
1161-1172
Language
english
Abstract
Among the major families of voltage-gated Ca(2+) channels, the low-voltage-activated channels formed by the Ca(v)3 subunits, referred to as T-type Ca(2+) channels, have recently gained increased interest in terms of the intracellular Ca(2+) signals generated upon their activation. Here, we provide an overview of recent reports documenting that T-type Ca(2+) channels act as an important Ca(2+) source in a wide range of neuronal cell types. The work is focused on T-type Ca(2+) channels in neurons, but refers to non-neuronal cells in cases where exemplary functions for Ca(2+) entering through T-type Ca(2+) channels have been described. Notably, Ca(2+) influx through T-type Ca(2+) channels is the predominant Ca(2+) source in several neuronal cell types and carries out specific signaling roles. We also emphasize that Ca(2+) signaling through T-type Ca(2+) channels occurs often in select subcellular compartments, is mediated through strategically co-localized targets, and is exploited for unique physiological functions.
Pubmed
Web of science
Open Access
Yes
Create date
26/02/2009 14:37
Last modification date
01/10/2019 6:17
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