18F- FDG PET/CT-derived parameters predict clinical stage and prognosis of esophageal cancer.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_268491541B6B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
18F- FDG PET/CT-derived parameters predict clinical stage and prognosis of esophageal cancer.
Journal
BMC medical imaging
Author(s)
Mantziari S., Pomoni A., Prior J.O., Winiker M., Allemann P., Demartines N., Schäfer M.
ISSN
1471-2342 (Electronic)
ISSN-L
1471-2342
Publication state
Published
Issued date
22/01/2020
Peer-reviewed
Oui
Volume
20
Number
1
Pages
7
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Although <sup>18</sup> F- FDG PET/CT is validated in baseline workup of esophageal cancer to detect distant metastases, it remains underused in assessing local staging and biology of the primary tumor. This study aimed to evaluate the association between <sup>18</sup> F- FDG PET/CT-derived parameters of esophageal cancer, and its clinico-pathological features and prognosis.
All patients (n = 86) with esophageal adenocarcinoma or squamous cell cancer operated between 2005 and 2014 were analyzed. Linear regression was used to identify clinico-pathologic features of esophageal cancer associated with the tumor's maximal Standardized Uptake Value (SUV <sub>max</sub> ), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV). ROC curve analysis was performed to precise the optimal cutoff of each variable associated with a locally advanced (cT3/4) status, long-term survival and recurrence. Kaplan Meier curves and Cox regression were used for survival analyses.
High baseline SUV <sub>max</sub> was associated with cT3/4 status and middle-third tumor location, TLG with a cT3/4 and cN+ status, whereas MTV only with active smoking. A cT3/4 status was significantly predicted by a SUV <sub>max</sub> > 8.25 g/mL (p < 0.001), TLG > 41.7 (p < 0.001) and MTV > 10.70 cm <sup>3</sup> (p < 0.01) whereas a SUV <sub>max</sub> > 12.7 g/mL was associated with an early tumor recurrence and a poor disease-free survival (median 13 versus 56 months, p = 0.030), particularly in squamous cell cancer.
Baseline <sup>18</sup> F- FDG PET/CT has a high predictive value of preoperative cT stage, as its parameters SUV <sub>max</sub> , TLG and MTV can predict a locally advanced tumor with high accuracy. A SUV <sub>max</sub> > 12.7 g/mL may herald early tumor recurrence and poor disease-free survival.
Keywords
18FDG PET/CT, Esophageal cancer, Metabolic imaging, Nuclear imaging, TNM stage
Pubmed
Create date
29/01/2020 18:05
Last modification date
15/01/2021 8:08
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