Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member.

Details

Serval ID
serval:BIB_2683817E543A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member.
Journal
Current Opinion in Lipidology
Author(s)
Michalik L., Desvergne B., Wahli W.
ISSN
0957-9672[print], 0957-9672[linking]
Publication state
Published
Issued date
2003
Volume
14
Number
2
Pages
129-135
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeostasis. Compared with the alpha and gamma peroxisome proliferator-activated receptor isotypes, peroxisome proliferator-activated receptor beta functions have long remained an enigma. In this review, we focus on emerging knowledge about peroxisome proliferator-activated receptor beta activation and roles. RECENT FINDINGS: We review recent data that suggest key roles in basic cell functions, such as proliferation, differentiation and survival, and in embryonic development and lipid metabolism in peripheral tissues. SUMMARY: The newly unveiled roles of peroxisome proliferator-activated receptor beta in important basic cell functions certainly justify a further exploration of its potential as a therapeutic target in pathologies such as metabolic syndrome X or skin diseases.
Keywords
Animals, Colonic Neoplasms/metabolism, Humans, Inflammation, Lipid Metabolism, Protein Isoforms/metabolism, Receptors, Cytoplasmic and Nuclear/metabolism, Transcription Factors/metabolism
Pubmed
Web of science
Create date
24/01/2008 15:27
Last modification date
20/08/2019 13:05
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