Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.

Details

Serval ID
serval:BIB_2678C7F17716
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
Journal
American Journal of Epidemiology
Author(s)
Fernández-Rhodes L., Demerath E.W., Cousminer D.L., Tao R., Dreyfus J.G., Esko T., Smith A.V., Gudnason V., Harris T.B., Launer L., McArdle P.F., Yerges-Armstrong L.M., Elks C.E., Strachan D.P., Kutalik Z., Vollenweider P., Feenstra B., Boyd H.A., Metspalu A., Mihailov E., Broer L., Zillikens M.C., Oostra B., van Duijn C.M., Lunetta K.L., Perry J.R., Murray A., Koller D.L., Lai D., Corre T., Toniolo D., Albrecht E., Stöckl D., Grallert H., Gieger C., Hayward C., Polasek O., Rudan I., Wilson J.F., He C., Kraft P., Hu F.B., Hunter D.J., Hottenga J.J., Willemsen G., Boomsma D.I., Byrne E.M., Martin N.G., Montgomery G.W., Warrington N.M., Pennell C.E., Stolk L., Visser J.A., Hofman A., Uitterlinden A.G., Rivadeneira F., Lin P., Fisher S.L., Bierut L.J., Crisponi L., Porcu E., Mangino M., Zhai G., Spector T.D., Buring J.E., Rose L.M., Ridker P.M., Poole C., Hirschhorn J.N., Murabito J.M., Chasman D.I., Widen E., North K.E., Ong K.K., Franceschini N.
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
178
Number
3
Pages
451-460
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.
Pubmed
Web of science
Open Access
Yes
Create date
08/09/2013 9:44
Last modification date
20/08/2019 13:05
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