Chromatin three-dimensional interactions mediate genetic effects on gene expression.

Details

Serval ID
serval:BIB_266A5EFF0381
Type
Article: article from journal or magazin.
Collection
Publications
Title
Chromatin three-dimensional interactions mediate genetic effects on gene expression.
Journal
Science
Author(s)
Delaneau O., Zazhytska M., Borel C., Giannuzzi G., Rey G., Howald C., Kumar S., Ongen H., Popadin K., Marbach D., Ambrosini G., Bielser D., Hacker D., Romano L., Ribaux P., Wiederkehr M., Falconnet E., Bucher P., Bergmann S., Antonarakis S.E., Reymond A., Dermitzakis E.T.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
03/05/2019
Peer-reviewed
Oui
Volume
364
Number
6439
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a dataset combining activity of regulatory elements, gene expression, and genetic variants across 317 individuals and two cell types. We show that variability in regulatory activity is structured at the intra- and interchromosomal levels within 12,583 cis-regulatory domains and 30 trans-regulatory hubs that highly reflect the local (that is, topologically associating domains) and global (that is, open and closed chromatin compartments) nuclear chromatin organization. These structures delimit cell type-specific regulatory networks that control gene expression and coexpression and mediate the genetic effects of cis- and trans-acting regulatory variants on genes.
Keywords
Chromatin/chemistry, Chromatin/metabolism, Gene Expression Regulation, Genetic Variation, Genome, Human, Humans, Quantitative Trait Loci, Regulatory Elements, Transcriptional
Pubmed
Web of science
Create date
16/05/2019 9:08
Last modification date
05/11/2019 7:10
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