Regulation of gastric and pancreatic lipase secretion by CCK and cholinergic mechanisms in humans.

Details

Serval ID
serval:BIB_2657
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Regulation of gastric and pancreatic lipase secretion by CCK and cholinergic mechanisms in humans.
Journal
The American journal of physiology
Author(s)
Borovicka J., Schwizer W., Mettraux C., Kreiss C., Remy B., Asal K., Jansen J.B., Douchet I., Verger R., Fried M.
ISSN
0002-9513
Publication state
Published
Issued date
1997
Volume
273
Number
2 Pt 1
Pages
G374-80
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Gastric lipase (HGL) contributes significantly to fat digestion. However, little is known about its neurohormonal regulation in humans. We studied the role of CCK and cholinergic mechanisms in the postprandial regulation of HGL and pancreatic lipase (HPL) secretion in six healthy subjects. Gastric emptying of a mixed meal and outputs of HGL, pepsin, acid, and HPL were determined with a double-indicator technique. Three experiments were performed in random order: intravenous infusion of 1) placebo, 2) low-dose atropine (5 micrograms.kg-.h-1), and 3) the CCK-A receptor antagonist loxiglumide (22 mumol.kg-.h-1). Atropine decreased postprandial outputs of HGL, pepsin, gastric acid, and HPL (P < 0.03) while slowing gastric emptying (P < 0.05). Loxiglumide markedly increased the secretion of HGL, pepsin, and acid while distinctly reducing HPL outputs and accelerating gastric emptying (P < 0.03). Plasma CCK and gastrin levels increased during loxiglumide infusion (P < 0.03). Atropine enhanced gastrin but not CCK release. Postprandial HGL, pepsin, and acid secretion are under positive cholinergic but negative CCK control, whereas HPL is stimulated by cholinergic and CCK mechanisms. We conclude that CCK and cholinergic mechanisms have an important role in the coordination of HGL and HPL secretion to optimize digestion of dietary lipids in humans.
Keywords
Adult, Cholecystokinin, Duodenum, Female, Gastric Acid, Gastric Emptying, Gastrins, Humans, Lipase, Male, Pancreas, Parasympathetic Nervous System, Stomach
Pubmed
Web of science
Create date
19/11/2007 12:23
Last modification date
20/08/2019 13:05
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