Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Details

Serval ID
serval:BIB_2651001652B2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of MCT1 Haploinsufficiency on the Mouse Retina.
Journal
Advances in experimental medicine and biology
Author(s)
Peachey N.S., Yu M., Han JYS, Lengacher S., Magistretti P.J., Pellerin L., Philp N.J.
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
1074
Pages
375-380
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 <sup>+/-</sup> heterozygotes, which express half of the normal complement of MCT1. The MCT1 <sup>+/-</sup> retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
Keywords
Animals, Electroretinography, Energy Metabolism, Evoked Potentials, Visual, Heterozygote, Lactates/metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Monocarboxylic Acid Transporters/deficiency, Monocarboxylic Acid Transporters/genetics, Monocarboxylic Acid Transporters/metabolism, Motor Neurons/metabolism, Oligodendroglia/metabolism, Photoreceptor Cells, Vertebrate/metabolism, Retina/metabolism, Retinal Bipolar Cells/metabolism, Symporters/deficiency, Symporters/genetics, Symporters/metabolism, Electroretinogram, Lactate, MCT1, Retina, Transgenic mice
Pubmed
Web of science
Create date
12/05/2018 11:17
Last modification date
21/08/2019 6:35
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