Relationship between ceftriaxone use and resistance of Enterobacter species

Details

Serval ID
serval:BIB_2646610FE829
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relationship between ceftriaxone use and resistance of Enterobacter species
Journal
Journal of Clinical Pharmacy and Therapeutics
Author(s)
Conus  P., Francioli  P.
ISSN
0269-4727 (Print)
Publication state
Published
Issued date
10/1992
Volume
17
Number
5
Pages
303-5
Notes
Journal Article --- Old month value: Oct
Abstract
We investigated the relationship between the amount of ceftriaxone used in our hospital and the evolution of the rate of resistance among Enterobacter species isolates. We reviewed all positive microbiological reports for Enterobacter species and the pharmacy records for the ceftriaxone consumption during four semesters over 4 consecutive years. The resistance to ceftriaxone among Enterobacter species rose from 10 to 27% while the amount of ceftriaxone used almost trebled during the study period. In order to investigate the relationship between the use of an antibiotic and the emergence of resistance to it, we studied the development of ceftriaxone resistance in Enterobacter species and the use of this drug at the Centre Hospitalier Universitaire Vaudois (CHUV) each year between 1983 and 1986. The consumption of ceftriaxone more than doubled between 1983 and 1984, and since then has increased only slowly. Within 2 years the rate of Enterobacter species resistance to ceftriaxone has jumped from about 10% between 1983 and 1985 to 27% in 1986. As no particular modification in the preventive methods of hospital hygiene and no epidemics occurred during the period of our study, we conclude that the increase in the prescribing of ceftriaxone probably played a central role in the increased number of resistant strains of Enterobacter species.
Keywords
Ceftriaxone/administration & dosage/*pharmacology/therapeutic use Drug Resistance, Microbial Drug Utilization Enterobacter/*drug effects/isolation & purification Humans Retrospective Studies Species Specificity
Pubmed
Web of science
Create date
25/01/2008 17:08
Last modification date
20/08/2019 13:04
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