TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth.

Details

Ressource 1Download: 2022 Communications Biology Sepporta.pdf (5174.21 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_2625E45392D6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth.
Journal
Communications biology
Author(s)
Sepporta M.V., Praz V., Balmas Bourloud K., Joseph J.M., Jauquier N., Riggi N., Nardou-Auderset K., Petit A., Scoazec J.Y., Sartelet H., Renella R., Mühlethaler-Mottet A.
ISSN
2399-3642 (Electronic)
ISSN-L
2399-3642
Publication state
Published
Issued date
12/01/2022
Peer-reviewed
Oui
Volume
5
Number
1
Pages
42
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The embryonic transcription factors TWIST1/2 are frequently overexpressed in cancer, acting as multifunctional oncogenes. Here we investigate their role in neuroblastoma (NB), a heterogeneous childhood malignancy ranging from spontaneous regression to dismal outcomes despite multimodal therapy. We first reveal the association of TWIST1 expression with poor survival and metastasis in primary NB, while TWIST2 correlates with good prognosis. Secondly, suppression of TWIST1 by CRISPR/Cas9 results in a reduction of tumor growth and metastasis colonization in immunocompromised mice. Moreover, TWIST1 knockout tumors display a less aggressive cellular morphology and a reduced disruption of the extracellular matrix (ECM) reticulin network. Additionally, we identify a TWIST1-mediated transcriptional program associated with dismal outcome in NB and involved in the control of pathways mainly linked to the signaling, migration, adhesion, the organization of the ECM, and the tumor cells versus tumor stroma crosstalk. Taken together, our findings confirm TWIST1 as promising therapeutic target in NB.
Keywords
General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Medicine (miscellaneous)
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2022 12:41
Last modification date
22/01/2022 7:32
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