Follicular fluid lipoproteins in preovulatory period and their relationship with follicular maturation and progesterone production by human granulosa-luteal cells in vivo and in vitro.

Details

Serval ID
serval:BIB_2623B0ED3713
Type
Article: article from journal or magazin.
Collection
Publications
Title
Follicular fluid lipoproteins in preovulatory period and their relationship with follicular maturation and progesterone production by human granulosa-luteal cells in vivo and in vitro.
Journal
Journal of Endocrinological Investigation
Author(s)
Volpe A., Coukos G., Uccelli E., Droghini F., Adamo R., Artini P.G.
ISSN
0391-4097 (Print)
ISSN-L
0391-4097
Publication state
Published
Issued date
1991
Volume
14
Number
9
Pages
737-742
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Follicular fluid (FF) lipoprotein content was evaluated in an in vitro fertilization/embryo transfer and gamete--intrafallopian--transfer program and correlated to follicular and oocyte maturation. Moreover, the in vitro progesterone response of granulosa-luteal cells from 10 patients to high-density lipoprotein (HDL) and to low-density lipoprotein (LDL) was assessed. Most FFs contained only HDL. Sixteen out of 97 FFs contained also very low levels of LDL and very-low-density lipoprotein (VLDL). The presence of LDL was associated to features of follicle and oocyte hypermaturity. LDL alone induced a much more potent increase of progesterone (P) release by granulosa-luteal cells than HDL alone, and the HDL partially reversed the potent effect of LDL. It is concluded that in late follicular phase HDL maintains P release by granulosa cells at a low rate and prevents a potent stimulation of P production by LDL which might cross the maturating blood-follicle barrier, until increasing passage of LDL in FF decreases the HDL:LDL ratio and the action of LDL becomes prominent.
Keywords
Female, Fertilization in Vitro, Follicular Fluid/metabolism, Gamete Intrafallopian Transfer, Granulosa Cells/metabolism, Humans, Lipoproteins/metabolism, Lipoproteins, HDL/metabolism, Lipoproteins, LDL/metabolism, Lipoproteins, VLDL/metabolism, Ovarian Follicle/physiology, Ovulation/physiology, Progesterone/biosynthesis
Pubmed
Web of science
Create date
14/10/2014 11:42
Last modification date
20/08/2019 13:04
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