Ocular melanoma: what's new?

Details

Serval ID
serval:BIB_261EE5091164
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ocular melanoma: what's new?
Journal
Current Opinion In Oncology
Author(s)
Leyvraz S., Keilholz U.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Publication state
Published
Issued date
2012
Volume
24
Number
2
Pages
162-169
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
PURPOSE OF REVIEW: The purpose of this review was to summarize available data on uveal melanoma biology and treatment in order to provide the medical community with a basic reference that would help to make further progress in this rare disease, which remains difficult to treat.¦RECENT FINDINGS: The most relevant recent findings driving current clinical developments are in the elucidation of uveal melanoma genetics and genomics. The key driving mutations - that differ completely from cutaneous melanoma - have been identified. Based on the novel insights into key signaling pathways, the first clinical trials with targeted treatments have been implemented. However, systemic and regional chemotherapy approaches as well as other regional treatment modalities for liver metastases are also a major part of the current treatment armamentarium and are prospectively being evaluated.¦SUMMARY: In summary, the recent biological findings and the creation of a series of clinical trials underscore how the international community is able to perform relevant advances in an extremely rare disease.
Keywords
Angiogenesis Inhibitors/therapeutic use, Antibodies, Monoclonal/therapeutic use, Antineoplastic Agents/therapeutic use, Chemotherapy, Adjuvant, Clinical Trials as Topic, GTP-Binding Protein alpha Subunits/genetics, Humans, Melanoma/genetics, Melanoma/metabolism, Mitogen-Activated Protein Kinases/metabolism, Signal Transduction/drug effects, Uveal Neoplasms/genetics, Uveal Neoplasms/metabolism
Pubmed
Web of science
Create date
06/06/2012 18:07
Last modification date
20/08/2019 13:04
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