The Atherosclerosis Burden score (ABS) : a convenient ultrasound-based score of peripheral atherosclerosis for coronary artery disease prediction

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Version: After imprimatur
Serval ID
serval:BIB_25B893D3AEA5
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
The Atherosclerosis Burden score (ABS) : a convenient ultrasound-based score of peripheral atherosclerosis for coronary artery disease prediction
Author(s)
YERLY Patrick-Olivier
Director(s)
Depairon Michèle, Darioli Roger
Institution details
Université de Lausanne, Faculté de biologie et médecine
Address
Faculté de biologie et de médecine
Université de Lausanne
CH-1015 Lausanne
SUISSE

Publication state
Accepted
Issued date
2017
Language
english
Abstract
Ultrasonographic detection of subclinical atherosclerosis improves cardiovascular risk stratification, but uncertainty persists about the most discriminative method to apply. In this study, we found that the Batherosclerosis burden score (ABS)^, a novel straightforward ultrasonographic score that sums the number of carotid and femoral arterial bifurcations with plaques, significantly outperformed common carotid intimamedia thickness, carotid mean/maximal thickness, and carotid/femoral plaque scores for the detection of coronary artery disease (CAD) (receiver operating characteristic (ROC) curve area under the curve (AUC)=0.79; P=0.027 to <0.001 with the other five US endpoints) in 203 patients undergoing coronary angiography. ABS was also more correlated with CAD extension (R=0.55; P<0.001). Furthermore, in a second group of 1128 patients without cardiovascular disease, ABS was weakly correlated with the European Society of Cardiology chart risk categories (R2 =0.21), indicating that ABS provided information beyond usual cardiovascular risk factor-based risk stratification. Pending prospective studies on hard cardiovascular endpoints, ABS appears as a promising tool in primary prevention.

Create date
18/12/2017 13:20
Last modification date
20/08/2019 14:04
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