Development of spatial integration depends on top-down and interhemispheric connections that can be perturbed in migraine: a DCM analysis.

Details

Serval ID
serval:BIB_2582C59EC816
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Development of spatial integration depends on top-down and interhemispheric connections that can be perturbed in migraine: a DCM analysis.
Journal
Neurological Sciences
Author(s)
Fornari E., Rytsar R., Knyazeva M.G.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Publication state
Published
Issued date
2014
Volume
35
Number
Suppl. 1
Pages
215-224
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
In humans, spatial integration develops slowly, continuing through childhood into adolescence. On the assumption that this protracted course depends on the formation of networks with slowly developing top-down connections, we compared effective connectivity in the visual cortex between 13 children (age 7-13) and 14 adults (age 21-42) using a passive perceptual task. The subjects were scanned while viewing bilateral gratings, which either obeyed Gestalt grouping rules [colinear gratings (CG)] or violated them [non-colinear gratings (NG)]. The regions of interest for dynamic causal modeling were determined from activations in functional MRI contrasts stimuli > background and CG > NG. They were symmetrically located in V1 and V3v areas of both hemispheres. We studied a common model, which contained reciprocal intrinsic and modulatory connections between these regions. An analysis of effective connectivity showed that top-down modulatory effects generated at an extrastriate level and interhemispheric modulatory effects between primary visual areas (all inhibitory) are significantly weaker in children than in adults, suggesting that the formation of feedback and interhemispheric effective connections continues into adolescence. These results are consistent with a model in which spatial integration at an extrastriate level results in top-down messages to the primary visual areas, where they are supplemented by lateral (interhemispheric) messages, making perceptual encoding more efficient and less redundant. Abnormal formation of top-down inhibitory connections can lead to the reduction of habituation observed in migraine patients.
Pubmed
Web of science
Create date
13/06/2014 12:23
Last modification date
20/08/2019 14:04
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