Antagonistic PCP Signaling Pathways in the developing Drosophila eye.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_24EB2C7F83F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antagonistic PCP Signaling Pathways in the developing Drosophila eye.
Journal
Scientific reports
Author(s)
Katanaev V.L., Egger-Adam D., Tomlinson A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
10/04/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
5741
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In Planar cell polarity (PCP), cells coordinately polarize their cytoskeletons within the plane of the epithelium in which they lie. In most insect epithelia this is indicated by the coordinated projections of the hairs secreted by the ectodermal cells. PCP of this form has been effectively studied in Drosophila, but it has proven difficult to achieve an integrated description of the roles played by the various proteins. In the insect eye, PCP is not evident as the polarization of individual cells, but as the asymmetric arrangements of the cells of the ommatidia. This different form of PCP allows different studies to be performed, and using this system we have detected the action of two antagonistic signaling pathways. Even though antagonistic, the two pathways synergize and cooperate to ensure that the correct arrangement of the cells is achieved. The cooperative use of antagonistic signaling pathways occurs in the polarization of chemotacting cells, and we discuss the possibility that a similar molecular principle may underlie PCP.
Keywords
Animals, Animals, Genetically Modified, Biomarkers, Cell Polarity, Drosophila/embryology, Drosophila/metabolism, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Eye/embryology, Eye/metabolism, Mutation, Organogenesis, Protein Binding, Signal Transduction, rhoA GTP-Binding Protein/genetics, rhoA GTP-Binding Protein/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
14/04/2018 9:02
Last modification date
17/09/2020 8:23
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