Matrix metalloproteinases and TIMP in acute respiratory distress syndrome.

Details

Serval ID
serval:BIB_24DDBDD90BF5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Matrix metalloproteinases and TIMP in acute respiratory distress syndrome.
Journal
American Journal of Respiratory and Critical Care Medicine
Author(s)
Ricou B., Nicod L., Lacraz S., Welgus H.G., Suter P.M., Dayer J.M.
ISSN
1073-449X[print], 1073-449X[linking]
Publication state
Published
Issued date
1996
Volume
154
Number
2 Pt 1
Pages
346-352
Language
english
Abstract
To investigate the implication of extracellular matrix proteinases in acute respiratory distress syndrome (ARDS), we determined 92 kD gelatinase (92 G'ase) and its natural antagonist, the tissue inhibitor of metalloproteinases-1 (TIMP) in bronchoalveolar lavage fluid (BALF) and plasma of 33 intensive care unit (ICU) patients presenting with trauma or septic shock. Eleven of these patients developed short-course ARDS, nine developed prolonged ARDS, and 13 did not progress to ARDS. Ten non-ICU patients served as controls. During the early phase of disease, 92 G'ase in BALF of ICU patients was higher than in controls, but plasma levels were not different. TIMP was increased in BALF and plasma in ARDS as compared with those of patients at risk. The 92 G'ase/TIMP ratio in BALF remained elevated in late phases of prolonged ARDS. The high intrapulmonary levels of 92 G'ase in patients at risk and with ARDS may reflect increased turnover of extracellular matrix in acute lung injury. Increased TIMP may interfere with tissue repair and fibrosis by its inhibition of 92 G'ase. Interleukin-6 (IL-6) could be involved in enhanced local synthesis of TIMP. The balance between 92 G'ase and TIMP may play an important role in lung remodeling, which is characteristic of ARDS.
Keywords
Adult, Bronchoalveolar Lavage Fluid/chemistry, Bronchoalveolar Lavage Fluid/cytology, Case-Control Studies, Collagenases/antagonists & inhibitors, Collagenases/metabolism, Enzyme-Linked Immunosorbent Assay, Female, Glycoproteins/metabolism, Humans, Interleukin-6/metabolism, Male, Matrix Metalloproteinase 9, Middle Aged, Multiple Trauma/complications, Multiple Trauma/metabolism, Protease Inhibitors/metabolism, Respiratory Distress Syndrome, Adult/epidemiology, Respiratory Distress Syndrome, Adult/etiology, Risk Factors, Shock, Septic/complications, Shock, Septic/metabolism, Time Factors, Tissue Inhibitor of Metalloproteinases
Pubmed
Web of science
Create date
19/02/2010 18:37
Last modification date
20/08/2019 13:03
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