An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.
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State: Public
Version: author
State: Public
Version: author
Serval ID
serval:BIB_24CF01F3D5E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.
Journal
Cancer Causes and Control
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
22
Number
9
Pages
1217-1231
Language
english
Abstract
BACKGROUND: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. METHODS: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. RESULTS: ORs were increased in underweight (<18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories (>/=25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers. CONCLUSIONS: The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified.
Keywords
Alcohol Drinking/adverse effects, Alcohol Drinking/epidemiology, Body Mass Index, Case-Control Studies, Female, Humans, Hypopharyngeal Neoplasms/epidemiology, Hypopharyngeal Neoplasms/etiology, Laryngeal Neoplasms/epidemiology, Laryngeal Neoplasms/etiology, Male, Mouth Neoplasms/epidemiology, Mouth Neoplasms/etiology, Odds Ratio, Oropharyngeal Neoplasms/epidemiology, Oropharyngeal Neoplasms/etiology, Risk Factors, Sex Factors, Smoking/adverse effects, Smoking/epidemiology
Pubmed
Web of science
Create date
02/08/2011 14:58
Last modification date
20/08/2019 14:03