NIH conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection

Details

Serval ID
serval:BIB_24C6D8C6BE22
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
NIH conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection
Journal
Annals of Internal Medicine
Author(s)
Fauci  A. S., Schnittman  S. M., Poli  G., Koenig  S., Pantaleo  G.
ISSN
0003-4819 (Print)
Publication state
Published
Issued date
04/1991
Volume
114
Number
8
Pages
678-93
Notes
Journal Article
Review --- Old month value: Apr 15
Abstract
An understanding of the immunopathogenic mechanisms of infection with human immunodeficiency virus (HIV) is fundamental in developing successful approaches to designing effective therapeutic and vaccine strategies. In this regard, we have investigated the mechanisms by which HIV inserts itself into the human immune system and uses the elaborate cytokine network to its own replicative advantage. We have also shown that the burden of HIV in CD4+ T cells is directly associated with a decline in this cell population in vivo and a progression to disease. Mononuclear phagocytes may play a role in the pathogenesis of HIV infection by serving as reservoirs of the virus. Of note is the fact that monocytes in the peripheral blood of HIV-infected individuals are rarely infected in vivo, whereas infected-tissue macrophages may play a role in organ-specific HIV-related pathogenesis. The role of HIV-specific humoral and cell-mediated immunity in HIV infection is not well understood. However, fine specificity of responses against HIV have been delineated in some in-vitro systems. It is unclear why these responses, particularly HIV-specific cytolytic T-cell responses, diminish over the course of infection and are unable to contain progression of infection.
Keywords
Acquired Immunodeficiency Syndrome/immunology CD4-Positive T-Lymphocytes/microbiology HIV Infections/*immunology/microbiology HIV-1/physiology Humans Immune System/*physiopathology Immunity Monocytes/physiology T-Lymphocytes, Cytotoxic/physiology
Pubmed
Web of science
Create date
25/01/2008 16:13
Last modification date
20/08/2019 14:03
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