A new life for an old pump: V-ATPase and neurotransmitter release.

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Serval ID
serval:BIB_24C475F2A713
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Title
A new life for an old pump: V-ATPase and neurotransmitter release.
Journal
Journal of Cell Biology
Author(s)
Vavassori S., Mayer A.
ISSN
1540-8140 (Electronic)
ISSN-L
0021-9525
Publication state
Published
Issued date
2014
Volume
205
Number
1
Pages
7-9
Language
english
Abstract
Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.
Pubmed
Web of science
Open Access
Yes
Create date
15/05/2014 8:14
Last modification date
20/08/2019 13:03
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