Assembly and fission of tubular carriers mediating protein sorting in endosomes.

Details

Serval ID
serval:BIB_24A579B5030D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assembly and fission of tubular carriers mediating protein sorting in endosomes.
Journal
Nature reviews. Molecular cell biology
Author(s)
Gopaldass N., Chen K.E., Collins B., Mayer A.
ISSN
1471-0080 (Electronic)
ISSN-L
1471-0072
Publication state
Published
Issued date
10/2024
Peer-reviewed
Oui
Volume
25
Number
10
Pages
765-783
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Endosomes are central protein-sorting stations at the crossroads of numerous membrane trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and cellular signalling and are involved in the pathogenesis of numerous diseases. Endosome-associated protein assemblies or coats collect transmembrane cargo proteins and concentrate them into retrieval domains. These domains can extend into tubular carriers, which then pinch off from the endosomal membrane and deliver the cargoes to appropriate subcellular compartments. Here we discuss novel insights into the structure of a number of tubular membrane coats that mediate the recruitment of cargoes into these carriers, focusing on sorting nexin-based coats such as Retromer, Commander and ESCPE-1. We summarize current and emerging views of how selective tubular endosomal carriers form and detach from endosomes by fission, highlighting structural aspects, conceptual challenges and open questions.
Keywords
Endosomes/metabolism, Humans, Protein Transport, Animals, Sorting Nexins/metabolism, Sorting Nexins/genetics, Vesicular Transport Proteins/metabolism, Vesicular Transport Proteins/genetics
Pubmed
Web of science
Create date
20/06/2024 16:19
Last modification date
28/09/2024 7:09
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