Glicoprotein (GP) IIb/IIIa inhibitors for acute stroke treatment.

Details

Serval ID
serval:BIB_24965
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glicoprotein (GP) IIb/IIIa inhibitors for acute stroke treatment.
Journal
Clinical and Experimental Hypertension
Author(s)
Bogousslavsky J., Paciaroni M., Gallai V.
ISSN
1064-1963 (Print)
ISSN-L
1064-1963
Publication state
Published
Issued date
2002
Volume
24
Number
7-8
Pages
603-610
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The benefit of antiplatelet therapy remains unclear, although it does appear that aspirin monotherapy started within 48 hours of stroke onset may result in a modest clinical improvement. Glicoprotein (GP) IIb/IIIa antagonists are currently considered the most powerful specific inhibitors of platelet activation in acute thrombosis. Glicoprotein IIb/IIIa inhibitor therapy could merit a prominent role also in the initial management of patients with acute ischemic stroke. Abciximab may be promising in this setting and should be evaluated in further clinical trials.
Keywords
Brain Ischemia/drug therapy, Fibrinolytic Agents/therapeutic use, Humans, North America, Platelet Activation/drug effects, Platelet Aggregation Inhibitors/therapeutic use, Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors, Platelet Glycoprotein GPIIb-IIIa Complex/therapeutic use, Randomized Controlled Trials as Topic, Stroke/drug therapy, Tissue Plasminogen Activator/therapeutic use, Treatment Outcome
Pubmed
Web of science
Create date
19/11/2007 12:21
Last modification date
20/08/2019 13:02
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