A randomized comparison of total extracorporeal CO2 removal with conventional mechanical ventilation in experimental hyaline membrane disease

Details

Serval ID
serval:BIB_248EE3D5E4F2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A randomized comparison of total extracorporeal CO2 removal with conventional mechanical ventilation in experimental hyaline membrane disease
Journal
Intensive Care Medicine
Author(s)
Dorrington  K. L., McRae  K. M., Gardaz  J. P., Dunnill  M. S., Sykes  M. K., Wilkinson  A. R.
ISSN
0342-4642 (Print)
Publication state
Published
Issued date
1989
Volume
15
Number
3
Pages
184-91
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Apnoeic oxygenation (AO) combined with extracorporeal CO2 removal (ECCO2R), using venovenous perfusion across a membrane area of 0.1 m2 has been shown to be feasible in six healthy anaesthetized rabbits. In a further twelve rabbits, ECCO2R has been randomly compared with conventional mechanical ventilation (CMV) following saline lavage to induce respiratory failure. Blood gases were maintained for up to 6 h within the same range (PaO2 = 8-20 kPa, PaCO2 = 4-6 kPa) in two groups of six by varying airway pressures and the oxygen fraction delivered either to the membrane lung (ECCO2R group) or to the ventilator (CMV group). The influence of single hourly sustained inflations (SI) on oxygenation was studied. ECCO2R subjects remained stable and survived. CMV subjects deteriorated and had 80% mortality. Hyaline membranes were absent from ECCO2R subjects and present in all CMV subjects. The response to SI suggests that a lung volume recruitment is maintained during AO for up to 1 h but is ineffective during CMV.
Keywords
Animals Blood Gas Analysis Carbon Dioxide/*blood Extracorporeal Membrane Oxygenation/*methods Humans Hyaline Membrane Disease/blood/pathology/*therapy Infant, Newborn Prospective Studies Rabbits Random Allocation Respiration, Artificial/*methods
Pubmed
Web of science
Create date
28/01/2008 10:48
Last modification date
20/08/2019 13:02
Usage data