Temporal regularity of cerebral activity at rest correlates with slowness of reaction times in intellectual disability

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_2489023FA598
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Temporal regularity of cerebral activity at rest correlates with slowness of reaction times in intellectual disability
Journal
Clinical Neurophysiology
Author(s)
Palix Julie, Giuliani Fabienne, Sierro Guillaume, Brandner Catherine, Favrod Jérôme
Publication state
Published
Issued date
08/06/2020
Peer-reviewed
Oui
Volume
131
Number
8
Pages
1859-1865
Language
english
Abstract
Objective
Intellectual disability (ID) is described as a general slowness in behavior and an inadequacy in adaptive skills. The present study examines whether behavioral slowness in ID could originate from abnormal complexity in brain signals.
Methods
Participants (N = 29) performed a reaction times (RTs) task assessing their individual information processing speeds. Half of the participants had moderate intellectual disability (intelligence quotient (IQ) < 70). Continuous electroencephalogram recording during the resting period was used to quantify brain signal complexity by approximate entropy estimation (ApEn).
Results
For all participants, a negative correlation between RTs and IQ was found, with longer RTs coinciding with lower IQ. This behavioral slowness in ID was associated with increased temporal regularity in electrocortical brain signals.
Conclusions
Behavioral slowness in ID subjects is closely related to lower brain signal complexity.
Significance
Brain signal ApEn is shown to correspond with processing speed for the first time: in ID participants, the higher the regularity in brain signals at rest, the slower RTs will be in the active state. ID should be understood as a lack of lability in the cortical transition to the active state, weakening the efficiency of adaptive behavior.
Keywords
Intellectual disability, EEG, resting state, approximate entropy, reaction times
Open Access
Yes
Create date
09/06/2020 11:06
Last modification date
21/07/2020 5:21
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