Assessment of adult formulas for glomerular filtration rate estimation in children.

Details

Ressource 1Download: serval:BIB_24272A0304B4.P001 (347.63 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_24272A0304B4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of adult formulas for glomerular filtration rate estimation in children.
Journal
Pediatric Nephrology
Author(s)
Chehade H., Girardin E., Iglesias K., Ramseyer P., Frey P., Bardy D., Mosig D., Cachat F.
ISSN
1432-198X (Electronic)
ISSN-L
0931-041X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
28
Number
1
Pages
105-114
Language
english
Notes
Publication types: Journal Article
Abstract
BACKGROUND: Estimated glomerular filtration rate (eGFR) is an important diagnostic instrument in clinical practice. The National Kidney Foundation-Kidney Disease Quality Initiative (NKF-KDOQI) guidelines do not recommend using formulas developed for adults to estimate GFR in children; however, studies confirming these recommendations are scarce. The aim of our study was to evaluate the accuracy of the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, the Modification of Diet in Renal Disease (MDRD) formula, and the Cockcroft-Gault formula in children with various stages of chronic kidney disease (CKD).
METHODS: A total of 550 inulin clearance (iGFR) measurements for 391 children were analyzed. The cohort was divided into three groups: group 1, with iGFR >90 ml/min/1.73 m(2); group 2, with iGFR between 60 and 90 ml/min/1.73 m(2); group 3, with iGFR of <60 ml/min/1.73 m(2).
RESULTS: All formulas overestimate iGFR with a significant bias (p < 0.001), present poor accuracies, and have poor Spearman correlations. For an accuracy of 10 %, only 11, 6, and 27 % of the eGFRs are accurate when using the MDRD, CKD-EPI, and Cockcroft-Gault formulas, respectively. For an accuracy of 30 %, these formulas do not reach the NKF-KDOQI guidelines for validation, with only 25, 20, and 70 % of the eGFRs, respectively, being accurate.
CONCLUSIONS: Based on our results, the performances of all of these formulas are unreliable for eGFR in children across all CKD stages and cannot therefore be applied in the pediatric population group.
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2012 19:34
Last modification date
01/10/2019 7:17
Usage data