Toxoplasmosis in Transplant Recipients, Europe, 2010-2014.

Details

Serval ID
serval:BIB_240DB6E502F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Toxoplasmosis in Transplant Recipients, Europe, 2010-2014.
Journal
Emerging infectious diseases
Author(s)
Robert-Gangneux F., Meroni V., Dupont D., Botterel F., Garcia JMA, Brenier-Pinchart M.P., Accoceberry I., Akan H., Abbate I., Boggian K., Bruschi F., Carratalà J., David M., Drgona L., Djurković-Djaković O., Farinas M.C., Genco F., Gkrania-Klotsas E., Groll A.H., Guy E., Hirzel C., Khanna N., Kurt Ö., Junie L.M., Lazzarotto T., Len O., Mueller N.J., Munoz P., Pana Z.D., Roilides E., Stajner T., van Delden C., Villena I., Pelloux H., Manuel O.
ISSN
1080-6059 (Electronic)
ISSN-L
1080-6040
Publication state
Published
Issued date
08/2018
Peer-reviewed
Oui
Volume
24
Number
8
Pages
1497-1504
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.
Keywords
Europe, Toxoplasma, cerebral toxoplasmosis, chemoprophylaxis, cotrimoxazole, hematopoietic stem cell transplant, parasites, toxoplasma infection, transplant recipient, transplantation
Pubmed
Web of science
Open Access
Yes
Create date
18/08/2018 9:11
Last modification date
20/08/2019 14:01
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