Pharmacokinetics of synthetic atrial natriuretic peptides in normal men.

Details

Serval ID
serval:BIB_23CA6AE7C186
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pharmacokinetics of synthetic atrial natriuretic peptides in normal men.
Journal
Clinical Pharmacology and Therapeutics
Author(s)
Biollaz J., Callahan L.T., Nussberger J., Waeber B., Gomez H.J., Blaine E.H., Brunner H.R.
ISSN
0009-9236 (Print)
ISSN-L
0009-9236
Publication state
Published
Issued date
1987
Peer-reviewed
Oui
Volume
41
Number
6
Pages
671-677
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The kinetics of atrial natriuretic peptides (ANP) and the kinetic profile of their effect on blood pressure and renal hemodynamic and electrolyte excretion were investigated in 20 salt-loaded healthy volunteers during and after constant rate infusion. At steady state, mean plasma concentrations of ANP were measured at 210, 430, and 2990 pg/ml and mean systemic clearance was 2.6, 2.5, and 1.7 L/min for ANP infusion rates of 0.5, 1, and 5 micrograms/min, respectively, which corresponds to the clearance rate of other vasoactive peptide hormones. The apparent volume of distribution averaged 17 L and the mean half-life was 4.5 minutes. ANP induced dose-related effects on systemic and renal hemodynamic, as well as urinary electrolyte excretion, albeit with a time lag between onset and full effect.
Keywords
Adult, Atrial Natriuretic Factor/blood, Atrial Natriuretic Factor/pharmacology, Blood Pressure/drug effects, Humans, Infusions, Intravenous, Kidney/drug effects, Kinetics, Male, Natriuresis/drug effects, Recombinant Proteins/blood, Recombinant Proteins/pharmacology
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 14:01
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