Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia

Details

Serval ID
serval:BIB_237C7D7FFF6F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia
Journal
Vet Res
Author(s)
Thepaut M., Grandjean T., Hober D., Lobert P. E., Bortolotti P., Faure K., Dessein R., Kipnis E., Guery B.
ISSN
1297-9716 (Electronic)
ISSN-L
0928-4249
Publication state
Published
Issued date
2015
Volume
46
Pages
91
Language
english
Notes
Thepaut, Marion
Grandjean, Teddy
Hober, Didier
Lobert, Pierre-Emmanuel
Bortolotti, Perrine
Faure, Karine
Dessein, Rodrigue
Kipnis, Eric
Guery, Benoit
eng
Research Support, Non-U.S. Gov't
England
Vet Res. 2015 Sep 4;46:91. doi: 10.1186/s13567-015-0239-3.
Abstract
The murine norovirus (MNV) is a recently discovered mouse pathogen, representing the most common contaminant in laboratory mouse colonies. Nevertheless, the effects of MNV infection on biomedical research are still unclear. We tested the hypothesis that MNV infection could alter immune response in mice with acute lung infection. Here we report that co-infection with MNV increases survival of mice with Pseudomonas aeruginosa acute lung injury and decreases in vivo production of pro-inflammatory cytokines. Our results suggest that MNV infection can deeply modify the parameters studied in conventional models of infection and lead to false conclusions in experimental models.
Keywords
Acute Disease, Animals, Caliciviridae Infections/*immunology/virology, Coinfection/immunology/microbiology/virology, Cytokines/*metabolism, *Immunomodulation, Male, Mice, Mice, Inbred C57BL, Norovirus/*physiology, Pneumonia/*immunology/microbiology, Pseudomonas Infections/*immunology/microbiology, Pseudomonas aeruginosa/physiology, Rodent Diseases/*immunology/microbiology/virology
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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