Role of the immune response induced by superantigens in the pathogenesis of microbial infections.

Details

Serval ID
serval:BIB_23510DB7C2FF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of the immune response induced by superantigens in the pathogenesis of microbial infections.
Journal
Parasitology
Author(s)
Maillard I., Luthi F., Acha-Orbea H., Diggelmann H.
ISSN
0031-1820 (Print)
ISSN-L
0031-1820
Publication state
Published
Issued date
1997
Volume
115 Suppl
Pages
S67-S78
Language
english
Abstract
Superantigens (SAgs) are microbial proteins which have potent effects on the immune system. They are presented by major histocompatibility complex (MHC) class II molecules and interact with a large number of T cells expressing specific T cell receptor V beta domains. Encounter of a SAg leads initially to the stimulation and subsequently to the clonal deletion of reactive T cells. SAgs are expressed by a wide variety of microorganisms which use them to exploit the immune system to their own advantage. Bacterial SAgs are exotoxins which are linked to several diseases in humans and animals. A classical example is the toxic shock syndrome in which the massive release of cytokines by SAg-reactive cells is thought to play a major pathogenic role. The best characterized viral SAg is encoded by mouse mammary tumour virus (MMTV) and has proved to have a major influence on the viral life cycle by dramatically increasing the efficiency of viral infection. In this paper, we review the general properties of SAgs and discuss the different types of microorganisms which produce these molecules, with a particular emphasis on the role played by the SAg-induced immune response in the course of microbial infections.
Keywords
Animals, Antigens, Bacterial/immunology, Antigens, Protozoan/immunology, Antigens, Viral/immunology, Bacterial Infections/immunology, Bacterial Infections/pathology, Humans, Superantigens/chemistry, Superantigens/classification, Toxoplasma/immunology, Toxoplasmosis/immunology, Virus Diseases/immunology, Virus Diseases/pathology
Pubmed
Web of science
Create date
24/01/2008 15:48
Last modification date
20/08/2019 14:00
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