Dietary acrylamide and human cancer

Details

Serval ID
serval:BIB_234C9D315978
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dietary acrylamide and human cancer
Journal
International Journal of Cancer
Author(s)
Pelucchi  Claudio, Galeone  Carlotta, Levi  Fabio, Negri  Eva, Franceschi  Silvia, Talamini  Renato, Bosetti  Cristina, Giacosa  Attilio, La Vecchia  Carlo
ISSN
0020-7136
Publication state
Published
Issued date
2006
Volume
118
Number
2
Pages
467-471
Notes
SAPHIRID:48665
Abstract
Low levels of acrylamide have been found in several foods cooked at high temperatures. While there is sufficient evidence for the carcinogenicity of acrylamide in experimental animals, the few epidemiologic studies conducted to date on occupational and dietary exposure to acrylamide have found no consistent evidence of association with human cancer risk. Using data from an integrated network of Italian and Swiss hospital-based case-control studies, we analyzed the relation between dietary acrylamide intake and cancers of the oral cavity and pharynx (749 cases, 1,772 controls), esophagus (395 cases, 1,066 controls), large bowel (1,394 cases of colon, 886 cases of rectal cancer, 4,765 controls), larynx (527 cases, 1,297 controls), breast (2,900 cases, 3,122 controls), ovary (1,031 cases, 2,411 controls) and prostate (1,294 cases, 1,451 controls). All the studies included incident, histologically confirmed cancer cases and controls admitted to the same network of hospitals for acute nonneoplastic conditions. We calculated odds ratios (ORs) using multivariate logistic regression models, adjusted for energy intake and other major covariates of interest. The ORs for the highest versus the lowest quintile of acrylamide intake were 1.12 (95% CI 5 0.76-1.66) for cancer of the oral cavity/pharynx, 1.10 (95% CI 5 0.65-1.86) for esophageal, 0.97 (95% CI 5 0.80-1.18) for colorectal, 1.23 (95% CI 5 0.80-1.90) for laryngeal, 1.06 (95% CI 5 0.88-1.28) for breast, 0.97 (95% CI 5 0.73-1.31) for ovarian and 0.92 (95% CI 5 0.69-1.23) for prostate cancer. None of the trend in risk was significant. This uniquely large and comprehensive data set does not show any consistent association between intake of acrylamide and the risk of breast and several other common cancers. [Ed.]
Keywords
Acrylamide , Diet , Neoplasms
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2008 14:58
Last modification date
20/08/2019 13:00
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