Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator.

Details

Serval ID
serval:BIB_231C885D761F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator.
Journal
JACC. Clinical electrophysiology
Author(s)
Haïssaguerre M., Sellal J.M., Benali K., de Becker B., Defaye P., Pascale P., Martins R., Mabo P., Xhaet O., Extramiana F., Surget E., Lavergne T., Marijon E., Adragao P., Carvalho M.S., Milliez P.U., Laredo M., Gandjbakhch E., Giustetto C., Gaita F., Tilz R., Jesel-Morel L., Steinfurt J., Arentz T., Knecht S., Duytschaever M., Roten L., Reichlin T., Fatemi M., Mansourati J., Kouakam C., Bessière F., Chevalier P., Tadros R., Macle L., Gallego F., Hadjis A., Sacher F., Pereira D., Hourdain J., Deharo J.C., Eschalier R., Massoulié G., Maury P., Latcu D.G., Anselme F., Duchateau J., Tixier R., Nademanee K., Nogami A., de Groot N., Vigmond E., Bernus O., Strik M., Bordachar P., Cathala A., Bouteiller X., Dubois R., Ploux S.
ISSN
2405-5018 (Electronic)
ISSN-L
2405-500X
Publication state
Published
Issued date
09/2024
Peer-reviewed
Oui
Volume
10
Number
9
Pages
1982-1994
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Idiopathic ventricular fibrillation (IVF) can be associated with undetected distinct conditions such as microstructural cardiomyopathic alterations (MiCM) or Purkinje (Purk) activities with structurally normal hearts.
This study sought to evaluate the characteristics of recurrent VF recorded on implantable defibrillator electrograms, associated with these substrates.
This was a multicenter collaboration study. At 32 centers, we selected patients with an initial diagnosis of IVF and recurrent arrhythmia at follow-up without antiarrhythmic drugs, in whom mapping demonstrated Purk or MiCM substrate. We analyzed variables related to previous ectopy, sinus rate preceding VF, trigger, and initial VF cycle lengths. Logistic regression with cross validation was used to evaluate the performance of criteria to discriminate Purk or MiCM substrates.
Among 95 patients (35 women, age 35 ± 11 years) meeting the inclusion criteria, IVF was associated with MiCM in 41 and Purk in 54 patients. A total of 117 arrhythmia recurrences including 91% VF were recorded on defibrillator. Three variables were mostly discriminant. Sinus tachycardia (≤570 ms) was more frequent in MiCM (35.9% vs 13.4%, P = 0.014) whereas short-coupled (<350 ms) triggers were most frequent in Purk-related VF (95.5% vs 23.1%, P = 0.001), which also had shorter VFCLs (182 ± 15 ms vs 215 ± 24 ms, P < 0.001).The multivariable combination provided the highest prediction (accuracy = 0.93 ± 0.05, range 0.833-1.000), discriminating 81% of IVF substrates with a high probability (>80%). Ectopy were inconsistently present before VF.
Characteristics of arrhythmia recurrences on implantable cardioverter- defibrillator provide phenotypic markers of the distinct and hidden substrates underlying IVF. These findings have significant clinical and genetic implications.
Keywords
Humans, Defibrillators, Implantable, Female, Ventricular Fibrillation/therapy, Ventricular Fibrillation/physiopathology, Male, Adult, Middle Aged, Recurrence, Cardiomyopathies/physiopathology, Cardiomyopathies/therapy, Cardiomyopathies/complications, Purkinje Fibers/physiopathology, Electrocardiography, Purkinje, cardiomyopathy, idiopathic ventricular fibrillation, implantable cardioverter-defibrillator, sudden cardiac death, ventricular fibrillation
Pubmed
Create date
12/07/2024 12:55
Last modification date
28/09/2024 7:09
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