Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine.

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Version: author
Serval ID
serval:BIB_2314A746CDE2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine.
Journal
Plos One
Author(s)
Siegrist C.A., van Delden C., Bel M., Combescure C., Delhumeau C., Cavassini M., Clerc O., Meier S., Hadaya K., Soccal P.M., Yerly S., Kaiser L., Hirschel B., Calmy A.
Working group(s)
H1N1 Study Group, Swiss HIV Cohort Study (SHCS)
Contributor(s)
Siegrist CA., Posfay-Barbe K., Meier S., Bel M., Grillet S., Sealy G., Demeules J., Charvat S., Verdon M., Combescure C., Hirschel B., Calmy A., Delhumeau-Cartier C., Gabay C., Guerne PA., Seebach J., Ribi C., Villard J., Dietrich PY., George AC., Favet L., van Delden C., Morard I., Mentha G., Giostra E., Hadaya K., Martin PY., Soccal P., Berney T., Noble S., Mohty B., Nagy M., Chalandon Y., Roosnek E., Passweg J., Kaiser L., Yerly S., Thomas Y., Wunderli W., Barth J., Battegay M., Bernasconi E., Böni J., Bucher HC., Burton-Jeangros C., Calmy A., Cavassini M., Cellerai C., Egger M., Elzi L., Fehr J., Fellay J., Flepp M., Francioli P., Furrer H., Fux CA., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch HH., Hirschel B., Hösli I., Kahlert C., Kaiser L., Keiser O., Kind C., Klimkait T., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Metzner K., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
7
Number
7
Pages
e40428
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Memory responses require immune competence. We assessed the influence of priming with AS03-adjuvanted pandemic vaccine (Pandemrix®) on memory responses of HIV patients, kidney recipients (SOT) and healthy controls (HC).
METHOD: Participants (HIV: 197, SOT: 53; HC: 156) were enrolled in a prospective study and 390/406 (96%) completed it. All had been primed in 2009/2010 with 1 (HC) or 2 (patients) doses of Pandemrix®, and were boosted with the 2010/2011 seasonal influenza vaccine. Geometric mean titres and seroprotection rates were measured 12 months after priming and 4 weeks after boosting. Primary and memory responses were directly compared in 191 participants (HCW: 69, HIV: 71, SOT: 51) followed during 2 consecutive seasons.
RESULTS: Most participants (HC: 77.8%, HIV: 77.6%, SOT: 66%) remained seroprotected at 12 months post-priming. Persisting A/09/H1N1 titers were high in HIV (100.2) and HC (120.1), but lower in SOT (61.4) patients. Memory responses reached higher titers in HIV (507.8) than in HC (253.5) and SOT (136.9) patients. Increasing age and lack of HAART reduced persisting and memory responses, mainly influenced by residual antibody titers. Comparing 2009/2010 and 2010/2011 titers in 191 participants followed for 2 seasons indicated lower post-2010/2011 titers in HC (240.2 vs 313.9), but higher titers in HIV (435.7 vs 338.0) and SOT (136 vs 90.3) patients.
CONCLUSIONS: Priming with 2 doses of Pandemrix® elicited persistent antibody responses and even stronger memory responses to non-adjuvanted seasonal vaccine in HIV patients than 1 dose in healthy subjects. Adjuvanted influenza vaccines may improve memory responses of immunocompromised patients.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01022905.
Keywords
Adult, Aged, Antibodies, Viral/blood, Antibodies, Viral/immunology, Female, HIV Infections/blood, HIV Infections/immunology, Humans, Immunocompromised Host, Immunologic Memory/drug effects, Influenza Vaccines/administration & dosage, Influenza, Human/blood, Influenza, Human/immunology, Kidney Transplantation/immunology, Male, Middle Aged, Pandemics
Pubmed
Web of science
Open Access
Yes
Create date
18/10/2012 18:10
Last modification date
20/08/2019 14:00
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