Combination antihypertensive therapy: does it have a role in rational therapy?

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Serval ID
serval:BIB_2310
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Combination antihypertensive therapy: does it have a role in rational therapy?
Journal
American Journal of Hypertension
Author(s)
Waeber B., Brunner H.R.
ISSN
0895-7061
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
10
Number
7 Pt 2
Pages
131S-137S
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The pharmacological treatment of hypertension allows one to reduce substantially the risk of developing a cardiovascular complication. It appears more and more important to bring blood pressure to normal values in order to get the maximal benefit from antihypertensive therapy. Blood pressure lowering drugs make it possible to control blood pressure in about half of the patients when administered as monotherapy. The fraction of patients with a normal blood pressure can be markedly increased by combining drugs acting by different mechanisms. Low doses of antihypertensive agents are generally enough when coadministered. This helps to keep the incidence of side effects minimal and facilitates the patient's compliance with long-term treatment. Low-dose, fixed-dose combination therapy may therefore represent a valuable option not only to treat hypertensive patients unresponsive to drugs given as monotherapy, but also to initiate the treatment.
Keywords
Antihypertensive Agents, Drug Therapy, Combination, Humans, Hypertension
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:18
Last modification date
25/09/2019 6:08
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