Impact of human variability on the biological monitoring of exposure to toluene. I. Physiologically based toxicokinetic modelling.

Details

Serval ID
serval:BIB_23003
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of human variability on the biological monitoring of exposure to toluene. I. Physiologically based toxicokinetic modelling.
Journal
Toxicology Letters
Author(s)
Tardif R., Droz P.O., Charest-Tardif G., Pierrehumbert G., Truchon G.
ISSN
0378-4274
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
134
Number
1-3
Pages
155-163
Language
english
Abstract
Using an approach involving physiologically based toxicokinetic (PBTK) modelling and Monte Carlo simulation (MCS), we investigated the impact of the biological variability affecting the parameters (e.g. physiological, physicochemical, biochemical) which determine toluene (TOL) kinetics on two exposure indicators (EIs): urinary excretion of o-cresol (o-CR), measured at the end of an 8 h exposure at 50 ppm, and unchanged TOL in blood (B-TOL) sampled prior to the last shift of a 5 day workweek. Population variance was described by assuming normal, or lognormal, distribution of parameter values and assigning to each one+/-2 S.D. (or+/-2 G.S.D.). PBTK-MCS (n=1000) resulted in a geometric mean (G.M.) of 0.635 mmol/mol creatinine for urinary o-CR, upper and lower limits (95%) ranging from 0.23 to 1.75, whereas, the GM for B-TOL was 120.6 microg/l (95% limits: 64.5-225.7). Overall, the results showed that this approach facilitates the prediction of the range of BEI values that could be anticipated to occur in a group of workers exposed to a chemical.
Keywords
Biological Markers, Cresols, Environmental Monitoring, Humans, Models, Biological, Monte Carlo Method, Occupational Exposure, Reproducibility of Results, Toluene
Pubmed
Web of science
Create date
19/11/2007 12:18
Last modification date
20/08/2019 13:00
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