Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition.

Details

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Serval ID
serval:BIB_22F4224FFE3C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition.
Journal
Cerebral Cortex (new York, N.y. : 1991)
Author(s)
Fischi-Gómez E., Vasung L., Meskaldji D.E., Lazeyras F., Borradori-Tolsa C., Hagmann P., Barisnikov K., Thiran J.P., Hüppi P.S.
ISSN
1460-2199 (Electronic)
ISSN-L
1047-3211
Publication state
Published
Issued date
2015
Volume
25
Number
9
Pages
2793-2805
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Extreme prematurity and pregnancy conditions leading to intrauterine growth restriction (IUGR) affect thousands of newborns every year and increase their risk for poor higher order cognitive and social skills at school age. However, little is known about the brain structural basis of these disabilities. To compare the structural integrity of neural circuits between prematurely born controls and children born extreme preterm (EP) or with IUGR at school age, long-ranging and short-ranging connections were noninvasively mapped across cortical hemispheres by connection matrices derived from diffusion tensor tractography. Brain connectivity was modeled along fiber bundles connecting 83 brain regions by a weighted characterization of structural connectivity (SC). EP and IUGR subjects, when compared with controls, had decreased fractional anisotropy-weighted SC (FAw-SC) of cortico-basal ganglia-thalamo-cortical loop connections while cortico-cortical association connections showed both decreased and increased FAw-SC. FAw-SC strength of these connections was associated with poorer socio-cognitive performance in both EP and IUGR children.
Keywords
Brain/anatomy & histology, Brain/physiology, Brain Mapping, Child, Cognition/physiology, Diffusion Tensor Imaging, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Infant, Premature, Male, Nerve Net/physiology, Neural Pathways/physiology, Neuropsychological Tests, Social Behavior
Pubmed
Web of science
Open Access
Yes
Create date
25/06/2014 9:52
Last modification date
25/09/2019 6:08
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