Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus.
Details
Serval ID
serval:BIB_22E4AF939CF7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus.
Journal
Fems Microbiology Letters
ISSN
0378-1097 (Print)
ISSN-L
0378-1097
Publication state
Published
Issued date
1992
Volume
71
Number
2
Pages
163-168
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.
Keywords
Amino Acid Sequence, Aspergillus fumigatus/genetics, Base Sequence, Cloning, Molecular, DNA Probes, Exons/genetics, Gene Library, Molecular Sequence Data, Nucleic Acid Hybridization, Sequence Homology, Nucleic Acid, Serine Endopeptidases/genetics, Serine Endopeptidases/secretion
Pubmed
Web of science
Create date
25/01/2008 16:46
Last modification date
20/08/2019 13:00
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