[Psychiatric patients and QT interval monitoring]

Details

Serval ID
serval:BIB_22BD49CF5772
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
[Psychiatric patients and QT interval monitoring]
Journal
Rev Med Suisse
Author(s)
Girardin F., Gaspoz J. M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2007
Volume
3
Number
106
Pages
945-8
Language
french
Notes
Girardin, F
Gaspoz, J M
fre
English Abstract
Review
Switzerland
Rev Med Suisse. 2007 Apr 11;3(106):945-8.
Abstract
Cardiovascular morbidity and mortality are higher in psychiatric patients than in the general population. In schizophrenic patients without cardiovascular history, long QT interval is a major risk factor for torsades de pointe and for sudden death. QT interval prolongation is a severe and underestimated dose-dependent adverse reaction triggered by several psychotropic drugs and by clinical situations such as polymedication, methadone maintenance treatment, electrolytic disturbances, cardiovascular history and congenital long QT syndromes. Systematic measurement of QT interval is recommended when psychotropic medications known to prolong it are introduced, as well as in clinical situations at risk. Stereoselective R-methadone administration (chiral switching) contributes to reduce the risk of QT prolongation.
Keywords
Death, Sudden/etiology, *Electrocardiography, Humans, Long QT Syndrome/chemically induced/diagnosis, Mental Disorders/complications/*drug therapy, Psychotropic Drugs/administration & dosage/*adverse effects, Torsades de Pointes/chemically induced/diagnosis
Pubmed
Create date
10/02/2021 11:32
Last modification date
11/02/2021 6:26
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