Characterization of Nedd4-2 ubiquitin ligase expression in experimental neuropathic pain

Details

Serval ID
serval:BIB_22B812FCED6E
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Characterization of Nedd4-2 ubiquitin ligase expression in experimental neuropathic pain
Title of the conference
Annual meeting of the Swiss Society of Anaesthesiology and Resuscitation
Author(s)
Cachemaille M., Laedermann C., Pertin M., Towne C., Abriel H., Decosterd I.
Address
Interlaken, Switzerland, October 29-31, 2009
ISBN
1424-7860
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
139
Series
Swiss Medical Weekly
Pages
3S-4S
Language
english
Notes
Meeting Abstract
Abstract
0.005). Nedd4-2 is mainly colocalized with markers of small neurons and almost absent in large neurons. In addition, Nedd4-2 is predominantly decreased in injured ATF3 positive cells.
Conclusion: Our results indicate that Nedd4-2 decreases Nav1.7 channels and currents at the cell membrane and that it is mainly expressed in nociceptors and downregulated after nerve injury. Taken together, our data suggest that the reduction of Nedd4-2, after nerve injury, modulates Nav1.7 activity and can contribute to neuropathic pain. We will further try to restore a normal level of Nedd4.2 via a gene therapy approach with viral vectors in order to soothe symptoms of neuropathic pain.
Web of science
Create date
18/11/2009 16:55
Last modification date
20/08/2019 13:00
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