Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_22B16FC3657F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis.
Journal
Frontiers in oncology
Author(s)
Chae W.H., Niesel K., Schulz M., Klemm F., Joyce J.A., Prümmer M., Brill B., Bergs J., Rödel F., Pilatus U., Sevenich L.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Publication state
Published
Issued date
27/11/2019
Peer-reviewed
Oui
Volume
9
Pages
1324
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Brain metastases are the most common intracranial tumor in adults and are associated with poor patient prognosis and median survival of only a few months. Treatment options for brain metastasis patients remain limited and largely depend on surgical resection, radio- and/or chemotherapy. The development and pre-clinical testing of novel therapeutic strategies require reliable experimental models and diagnostic tools that closely mimic technologies that are used in the clinic and reflect histopathological and biochemical changes that distinguish tumor progression from therapeutic response. In this study, we sought to test the applicability of magnetic resonance (MR) spectroscopy in combination with MR imaging to closely monitor therapeutic efficacy in a breast-to-brain metastasis model. Given the importance of radiotherapy as the standard of care for the majority of brain metastases patients, we chose to monitor the post-irradiation response by magnetic resonance spectroscopy (MRS) in combination with MR imaging (MRI) using a 7 Tesla small animal scanner. Radiation was applied as whole brain radiotherapy (WBRT) using the image-guided Small Animal Radiation Research Platform (SARRP). Here we describe alterations in different metabolites, including creatine and N-acetylaspartate, that are characteristic for brain metastases progression and lactate, which indicates hypoxia, while choline levels remained stable. Radiotherapy resulted in normalization of metabolite levels indicating tumor stasis or regression in response to treatment. Our data indicate that the use of MR spectroscopy in addition to MRI represents a valuable tool to closely monitor not only volumetrical but also metabolic changes during tumor progression and to evaluate therapeutic efficacy of intervention strategies. Adapting the analytical technology in brain metastasis models to those used in clinical settings will increase the translational significance of experimental evaluation and thus contribute to the advancement of pre-clinical assessment of novel therapeutic strategies to improve treatment options for brain metastases patients.
Keywords
brain metastases, magnetic resonance imaging, metabolites, pre-clinical models, radio-response, radiotherapy, spectroscopy
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2020 12:07
Last modification date
22/09/2020 7:08
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