Postnatal development of the amygdala: A stereological study in rats

Details

Serval ID
serval:BIB_22AF8B8D43C1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Postnatal development of the amygdala: A stereological study in rats
Journal
Journal of Comparative Neurology
Author(s)
Chareyron L.J., Banta Lavenex P., Lavenex P.
ISSN
1096-9861 (Electronic)
ISSN-L
0021-9967
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
520
Number
16
Pages
3745-3763
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
The amygdala is the central component of a functional brain system regulating fear and emotional behaviors. Studies of the ontogeny of fear behaviors reveal the emergence of distinct fear responses at different postnatal ages. Here, we performed a stereological analysis of the rat amygdala to characterize the cellular changes underlying its normal structural development. Distinct amygdala nuclei exhibited different patterns of postnatal development, which were largely similar to those we have previously shown in monkeys. The combined volume of the lateral, basal, and accessory basal nuclei increased by 113% from 1 to 3 weeks of age and by an additional 33% by 7 months of age. The volume of the central nucleus increased only 37% from 1 to 2 weeks of age and 38% from 2 weeks to 7 months. At 1 week of age, the medial nucleus was 77% of the 7-month-old's volume and exhibited a constant, marginal increase until 7 months. Neuron number did not differ in the amygdala from 1 week to 7 months of age. In contrast, astrocyte number decreased from 3 weeks to 2 months of age in the whole amygdala. Oligodendrocyte number increased in all amygdala nuclei from 3 weeks to 7 months of age. Our findings revealed that distinct amygdala nuclei exhibit different developmental profiles and that the rat amygdala is not fully mature for an extended period postnatally. We identified different periods of postnatal development of distinct amygdala nuclei and cellular components, which are concomitant with the ontogeny of different fear and emotional behaviors. J. Comp. Neurol. 520:3745-3763, 2012. © 2012 Wiley Periodicals, Inc.
Pubmed
Web of science
Create date
25/10/2012 13:29
Last modification date
20/08/2019 13:00
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