Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil.

Details

Ressource 1Download: serval:BIB_22A6580B8935.P001 (323.63 [Ko])
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Serval ID
serval:BIB_22A6580B8935
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil.
Journal
Intensive care medicine
Author(s)
Pittet Y.K., Berger M.M., Pluess T.T., Voirol P., Revelly J.P., Tappy L., Chioléro R.L.
ISSN
1432-1238 (Electronic)
ISSN-L
0342-4642
Publication state
Published
Issued date
02/2010
Peer-reviewed
Oui
Volume
36
Number
2
Pages
289-295
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To test the dose response effect of infused fish oil (FO) rich in n-3 PUFAs on the inflammatory response to endotoxin (LPS) and on membrane incorporation of fatty acids in healthy subjects.
Prospective, sequential investigation comparing three different FO doses.
Three groups of male subjects aged 26.8 +/- 3.2 years (BMI 22.5 +/- 2.1).
One of three FO doses (Omegaven10%) as a slow infusion before LPS: 0.5 g/kg 1 day before LPS, 0.2 g/kg 1 day before, or 0.2 g/kg 2 h before.
Temperature, hemodynamic variables, indirect calorimetry and blood samples (TNF-alpha, stress hormones) were collected. After LPS temperature, ACTH and TNF-alpha concentrations increased in the three groups: the responses were significantly blunted (p < 0.0001) compared with the control group of the Pluess et al. trial. Cortisol was unchanged. Lowest plasma ACTH, TNF-alpha and temperature AUC values were observed after a single 0.2 g/kg dose of FO. EPA incorporation into platelet membranes was dose-dependent.
Having previously shown that the response to LPS was reproducible, this study shows that three FO doses blunted it to various degrees. The 0.2 g/kg perfusion immediately before LPS was the most efficient in blunting the responses, suggesting LPS capture in addition to the systemic and membrane effects.

Keywords
Adolescent, Adrenocorticotropic Hormone/blood, Adrenocorticotropic Hormone/drug effects, Adult, Calorimetry, Indirect, Endotoxins/antagonists & inhibitors, Endotoxins/metabolism, Fish Oils/administration & dosage, Fish Oils/pharmacology, Fish Oils/therapeutic use, Humans, Infusions, Intravenous, Male, Prospective Studies, Sepsis/metabolism, Sepsis/therapy, Time Factors, Tumor Necrosis Factor-alpha/metabolism, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
08/02/2010 13:02
Last modification date
01/10/2019 7:17
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