Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area
Details
Serval ID
serval:BIB_2296E0A75394
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area
Journal
Parasite Immunology
ISSN
0141-9838 (Print)
Publication state
Published
Issued date
06/1997
Volume
19
Number
6
Pages
249-54
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jun
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jun
Abstract
A prospective study in 207 children aged 0.5-15 years was carried out to examine the relationship between cellular responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) and malaria infection and morbidity. The prevalence of lymphoproliferative response to RESA was 13%, IFN-gamma prevalence was 40% and IL-4 prevalence was 22%. Only the IFN-gamma, response to RESA increased significantly with age. When proliferation or stimulation of either cytokine was used to assess T-cell activation the overall frequency of responders increased to 55%. The proliferative and IFN-gamma response to RESA were positively associated. Although there was no association between any of the CMI responses to RESA and concurrent morbidity the prevalence of IL-4 response to RESA was significantly lower in children who experienced clinical malaria in the following year. These results coupled with our earlier data showing a negative relationship between humoral responses to RESA and malaria morbidity support the inclusion of RESA in a subunit vaccine against malaria.
Keywords
Adolescent
Animals
Antigens, Protozoan/*immunology
Cell Division
Cells, Cultured
Child
Child, Preschool
Cohort Studies
*Endemic Diseases
Humans
Infant
Interferon Type II/immunology
Interleukin-4/*immunology
Leukocytes, Mononuclear/cytology
Malaria/epidemiology/*immunology
Papua New Guinea/epidemiology
Plasmodium falciparum/*immunology
Prospective Studies
Protozoan Proteins/*immunology
Recombinant Fusion Proteins/immunology
T-Lymphocytes/*immunology
Pubmed
Web of science
Create date
28/01/2008 12:49
Last modification date
20/08/2019 14:00